Assisted a best in class NGS (Next Generation Sequencing) human diagnostic startup develop a sustainable, FDA compliant, and agile software development process. Managed a program to deliver a factory-based workflow application for a NGS DNA Super-Sequencer.
Helped an exciting and innovative IVD startup develop a best-of-class molecular diagnostic system. the company was recently purchased with an expansion in assay offerings and markets
Assisted a major biotechnology tools provider to develop a Manufacturing Execution System (MES) using industry standards, and off-the-shelf tools. When complete, this program will deliver a highly configurable system that leverages the ISA88 process standards. This Recipe-based MES allows a reduction in time to market from months to weeks, with no loss in quality, while improving traceability and reducing costs.
South Mountain Community College
January 2017-December 2018
Adjunct Faculty, Into to Biology for Majors
Applied Biosystems/Perkin-Elmer/Life Technologies
Tech Board Chair, Advanced Research & Technology, Business Development
Nov 2005 – Nov 2007
Responsible for the management of a group responsible for technology evaluations of potential technology acquisitions. In this role, Leslie developed and implemented a new technology review process and oversaw the automation of that process.
Sr Manager- SW, SDS/Arrays
May 2003 – Nov 2005
Responsible for the management of the SDS software for the 7000, 7300 and 7500 Real-time PCR systems including the validation of these systems for use in FDA regulated devices.
Sr Manager, DNA Sequencing and Fragment analysis software group
Aug 2001 – Nov 2002
Responsible for the management of the DNA sequencing and genotyping analysis software applications at AB, including Sequencing Analysis, GeneMapper®, SeqScape® Software, and the AB basecallers.
Responsible for the design and development and on-time delivery of SeqScape® Software.
Senior Staff Scientist/HIV Group leader
Jan 1996 – May 1999
Responsible for the inception, design, and management of a program to develop a clinical assay based on automated DNA sequence analysis to determine the genotypic resistance of HIV to antiviral compounds.
Scientist/Senior Scientist, Human Genetic Analysis R&D
June 1991- Dec 1996
Responsible for much of the initial work demonstrating the clinical applications of DNA sequencing technology. This initial work includes defining the requirements of the automated heterozygote calling and allele analysis software. Management of key collaborations both domestic and international was integral in this development program.
Associate Scientist, DNA Sequencing R&D
March 1989 – June 1991
Investigation of the applicability of existing and proposed ABI technology to the problem of high throughput genomic DNA sequencing. Through sequencing, a cosmid derived from human chromosome 19 modifications to existing protocols were identified that would facilitate this analysis.